The purpose of this paper is to suggest and introduce a framework, U-TELL, for disciplinary literacy instruction or research projects. The U-TELL framework was developed through a five-year disciplinary literacy research project, so disciplinary literacy, school-university partnership, and the overview of the project were discussed and presented. The U-TELL framework which involves five components: Uncoverage, Text, Engagement, Literacy, and Learning, was then introduced and discussed. Specifically, first, Uncoverage focuses on essential questions and on making disciplinary thinking visible. Second, Text involves teachers’ practices searching for, adapting, and creating relevant texts. Third, Engagement emphasizes incorporating multiliteracies to plan and create dynamic and relevant lessons. Fourth, Literacy includes practices that are tied to specific thinking skills and support students’ understanding of essential questions. Finally, Learning is the embodiment of students’ meaning-making from texts and understanding through active engagement.